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Autor[ Znker KS, Gottschalk G, Hans, S. J[ 24.4 Z. Phytother. 24, Nr. 4, 163-168 2003 ; Sicherheits- und Wirksamkeitsstudie mit einem Extrakt aus Momordica charantia bei Patienten mit Typ-2-Diabetes Safety and efficacy study of Momordica charantia extract in patients with type two Diabetes ; Zusammenfassung Zu ihrem pharmakologischen oder beratenden Therapieschema verzehrten 41 Diabetespatienten tglich vor zwei greren Mahlzeiten jeweils eine Kapsel mit 500 mg Mormordica-charantiaExtrakt. ber M. charantia Bitter Melon ; wird in der Literatur von einer Blutzucker senkenden Wirkung berichtet. Nach einer 6-monatigen Beobachtung konnte bei 21 41 Patienten gezeigt werden, dass der Nchternblutzuckerspiegel, der vor Beginn des Bitter-Melon-Verzehrs bis zu 200 mg dl betrug, um bis zu 25% vom Ausgangswert zu senken war und dass sich dabei das HbA1c durchschnittlich um 0, 5 Prozentpunkte erniedrigte. Im Einklang mit den Ergebnissen der UK Prospective Diabetes Study bedeutet dieses Ergebnis eine Risikosenkung fr Diabetessptfolgen um weitere 10% auf 42%. Daraus resultiert eine Verschiebung der Patienten aus der Gruppe Diabetes mellitus Typ 2 in die prognostisch gnstigere Gruppe gestrte Glukosetoleranz Nchternglukose 126 mg dl ; . Bitter Melon hat sich als eine sichere ergnzende bilanzierte Dit ohne produktspezifische Nebenwirkung erwiesen. Summary In an effort to establish and to document the hypoglycaemic activity of Momordica charantia L. bitter melon; Curcurbitaceae ; in diabetes, 41 non-insulin-dependent patients took a capsule filled with 500 mg M. charantia fruit extract respectively, before two daily meals in addition to pharmacological and or counselling therapies. Within a subgroup of moderate diabetes patients fasting glucose 200 mg dl and HbA1c 8.0% ; , the plasma glucose level could be depressed within 24 weeks of observation by 25% followed by a drop in HbA1c by 0.5 percent. In accordance with the UK Prospective Diabetes Study, this means an additional 10% of risk decrement for late diabetes associated diseases reaching all in all risk assessment of 42% oral diabetic therapy counselling plus bitter melon extract nutrition ; . Those patients belonging to the defined subgroup moderate diabetes patients ; could be brought, by taking Bitter Melon extract 500 mg ; daily, into the group of glucose intolerant subjects who are less prone to late and severe diabetes associated diseases. Bitter Melon extract at the concentration used turned out to be a safe nutraceutical without any toxic side effects. Keywords Momordica charantia, bitter melon, diabetes, NIDDM, plasma glucose level, HbA1c, charantin, nutraceutical, nutrition Autor[ Zitterl-Eglseer K, Reznicek G, Novak J, Franz Ch, Jurenitsch J J[ 21.3 Z. Phytother. 21, Nr. 3, 154-156 2000 ; Morphogenetische Variabilitt und Stabilitt von Faradiolmonoestern in Ringelblumen Morphogenetic variability and stability of faradiol monoesters in Marigold ; Zusammenfassung Morphogenetische Variabilittsuntersuchungen an Calendula officinalis L. zeigten den hchsten Gehalt an Faradiolmonoestern in den getrockneten Zungenblten, denen der Vorzug gegenber allen anderen Pflanzenteilen bei der Herstellung von Arzneizubereitungen gegeben, for example, metronidazole flagyl.
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O extrato da espcie medicinal Alternanthera brasiliana Kuntze forneceu seis derivados di- e triglicosilados de kaempferol e quercetina. As estruturas foram elucidadas com base em RMN de 1H e 13C. Os seis flavonides so inditos no gnero. Kaempferol 3-O-robinobiosdeo e kaempferol 3O-rutinosdeo inibiram mais eficientemente a proliferao de linfcitos humanos in vitro. The extract of the medicinal species Alternanthera brasiliana Kuntze afforded six di- and triglycosyl kaempferol and quercetin derivatives. Their structures were elucidated based on the 1Hand 13C-NMR data and are reported here for the first time in this genus. Kaempferol 3-O-robinobioside and kaempferol 3-O-rutinoside significantly inhibited the human lymphocyte proliferation in vitro. Keywords: Alternanthera brasiliana, Amaranthaceae, flavonol robinobiosides, flavonol rutinosides, lymphocyte proliferation and fluconazole.
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Pharmaceuticals Inspection Convention PIC S ; Die Zusammenarbeit mit der Pharmaceutical Inspection Convention Schemes PIC S ; und dem European Directorate for the Quality of Medicines EDQM ; ist seit langem gut etabliert. So stellte Swissmedic Inspektoren fr zwei in China durchgefhrte Inspektionskampagnen des Zertifizierungsprogramms der Europischen Pharmakope unter der Verantwortung der EDQM zur Verfgung. Die whrend der Erarbeitung der Regeln der Guten Herstellungspraxis fr Arzneimittel in kleinen Mengen gesammelten Erfahrungen erlaubten es Swissmedic, in der PIC S-Fachgruppe Spitalpharmazie einen massgeblichen Beitrag zur Erstellung vergleichbarer Regeln auf internationaler Ebene einzubringen. Weltgesundheitsorganisation WHO ; Swissmedic arbeitet mit der WHO in diversen Bereichen zusammen. Ein Engagement galt der Einfhrung von internationalen Regeln der Guten Herstellungspraxis im Blutspendewesen in Lndern Lateinamerikas. Eine weitere Zusammenarbeit betraf die Analyse von Impfstoffen oder die Beurteilung der Herstellung von Impfstoffen, welche von der WHO fr die Unicef geliefert werden.
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Behavioural pharmacology , 1 , 283-30 kerr, 1987, august 30.
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Many millions of Americans who have bone and joint health problems are gobbling aspirin and non-steroidal anti-inflammatory drugs NSAIDs ; in a manner that now presents a major public health concern. This concern is a direct consequence of the common and serious side effects that these drugs may produce. Unfortunately, the side effects of NSAIDs are sometimes fatal, especially in the elderly. Older people are the main target population that takes NSAIDs to manage their joint pain. Common side effects of NSAID include stomach upset, which can herald the onset of peptic ulcer, and life-threatening bleeding from the upper or lower digestive tract. Liver and kidney problems are also relatively common with NSAID use. Table 2 gives examples of NSAIDs and shows a list of natural supplements that have are beneficial for nutritional support of bone and joint health. For three decades, medical literature has issued warnings about the adverse effects of NSAIDs. These drugs are associated with more than 60 percent of all cases involving lifethreatening bleeding from the upper digestive tract. The dangers of NSAID use become acutely apparent when one recognizes that they are the most common reason for adverse drug side effects reported to the U.S. Food and Drug Administration FDA ; . For these reasons, many people have sought alternative health benefits of dietary supplements that have great advantage as nutritional support for bone and joint health. The study of Naturopathic Medicine natural medicines ; has resulted in the identification of a number of herbs which may inhibit Cox-2 enzymes in the body. Cox-2 enzymes are produced as part of normal body function in the presence of inflammation and they contribute to pain and disability that is Continued on Page 5 ; Table 2: NSAIDs, brand names of common NSAIDs and natural supplements with an endemic base for the nutritional support of bone and joint health NSAIDs.
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